Renal Functional Outcomes Following Primary Ureteroureterostomy Performed During Multi-organ Resection in Cancer Patients
CUA Online Library. Pisters A. 06/24/13; 31276; MP-04.04
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Abstract
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Abstract
Background: Multi-organ resection in patient with cancer may include ureteral resection. The resulting ureteral defect can be reconstructed with ureteroureterostomy (UU); however long-term renal function outcomes of UU in this patient group are unclear.
Objectives: In the current retrospective analysis, we evaluated renal function outcomes after UU to determine the long-term efficacy of this reconstruction.
Methods: We retrospectively reviewed the charts of patients who underwent UU between 1995 and 2012. Renal imaging studies performed before and after UU were used to determine whether hydronephrosis was present. Renal function was assessed by comparing estimated glomerular filtration rate (eGFR) before and after UU. Patients who developed cancer recurrence involving the UU were censored from further follow-up regarding renal function.
Results: Twenty four patients underwent UU during multi-organ resection. Median follow-up time was 52 months. One patient developed progressive hydronephrosis with a greater than 20% drop in eGFR from baseline. Six additional patients developed progressive hydronephrosis due to cancer recurrence involving the UU. Kidney function as assessed by eGFR was maintained in all of the remaining patients.
Conclusions: UU during multi-organ resection for cancer is safe and effective. Long-term renal function is maintained in the majority of patients.
Background: Multi-organ resection in patient with cancer may include ureteral resection. The resulting ureteral defect can be reconstructed with ureteroureterostomy (UU); however long-term renal function outcomes of UU in this patient group are unclear.
Objectives: In the current retrospective analysis, we evaluated renal function outcomes after UU to determine the long-term efficacy of this reconstruction.
Methods: We retrospectively reviewed the charts of patients who underwent UU between 1995 and 2012. Renal imaging studies performed before and after UU were used to determine whether hydronephrosis was present. Renal function was assessed by comparing estimated glomerular filtration rate (eGFR) before and after UU. Patients who developed cancer recurrence involving the UU were censored from further follow-up regarding renal function.
Results: Twenty four patients underwent UU during multi-organ resection. Median follow-up time was 52 months. One patient developed progressive hydronephrosis with a greater than 20% drop in eGFR from baseline. Six additional patients developed progressive hydronephrosis due to cancer recurrence involving the UU. Kidney function as assessed by eGFR was maintained in all of the remaining patients.
Conclusions: UU during multi-organ resection for cancer is safe and effective. Long-term renal function is maintained in the majority of patients.
Abstract
Background: Multi-organ resection in patient with cancer may include ureteral resection. The resulting ureteral defect can be reconstructed with ureteroureterostomy (UU); however long-term renal function outcomes of UU in this patient group are unclear.
Objectives: In the current retrospective analysis, we evaluated renal function outcomes after UU to determine the long-term efficacy of this reconstruction.
Methods: We retrospectively reviewed the charts of patients who underwent UU between 1995 and 2012. Renal imaging studies performed before and after UU were used to determine whether hydronephrosis was present. Renal function was assessed by comparing estimated glomerular filtration rate (eGFR) before and after UU. Patients who developed cancer recurrence involving the UU were censored from further follow-up regarding renal function.
Results: Twenty four patients underwent UU during multi-organ resection. Median follow-up time was 52 months. One patient developed progressive hydronephrosis with a greater than 20% drop in eGFR from baseline. Six additional patients developed progressive hydronephrosis due to cancer recurrence involving the UU. Kidney function as assessed by eGFR was maintained in all of the remaining patients.
Conclusions: UU during multi-organ resection for cancer is safe and effective. Long-term renal function is maintained in the majority of patients.
Background: Multi-organ resection in patient with cancer may include ureteral resection. The resulting ureteral defect can be reconstructed with ureteroureterostomy (UU); however long-term renal function outcomes of UU in this patient group are unclear.
Objectives: In the current retrospective analysis, we evaluated renal function outcomes after UU to determine the long-term efficacy of this reconstruction.
Methods: We retrospectively reviewed the charts of patients who underwent UU between 1995 and 2012. Renal imaging studies performed before and after UU were used to determine whether hydronephrosis was present. Renal function was assessed by comparing estimated glomerular filtration rate (eGFR) before and after UU. Patients who developed cancer recurrence involving the UU were censored from further follow-up regarding renal function.
Results: Twenty four patients underwent UU during multi-organ resection. Median follow-up time was 52 months. One patient developed progressive hydronephrosis with a greater than 20% drop in eGFR from baseline. Six additional patients developed progressive hydronephrosis due to cancer recurrence involving the UU. Kidney function as assessed by eGFR was maintained in all of the remaining patients.
Conclusions: UU during multi-organ resection for cancer is safe and effective. Long-term renal function is maintained in the majority of patients.
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